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May 2017 - Psychosis Research Unit
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May 2017

Young people at risk of psychosis: Their subjective experiences of monitoring and cognitive behaviour therapy in the early detection and intervention evaluation 2 trial

Rory E. Byrne and Anthony P. Morrison Full Article Abstract Objectives To explore participants' experiences of ‘enhanced monitoring’ and cognitive behaviour therapy (CBT) within a randomized controlled trial evaluating early detection and prevention of psychosis (‘early detection and intervention evaluation [EDIE] 2’). Design Semi-structured qualitative interviews were conducted with a sample of participants at the end of their involvement with the trial. Methods Ten young people were interviewed; six males and four females, with a mean age of 27.5. Nine participants identified themselves as White British and one Black British. All participants had received ‘enhanced monitoring’ during the trial, and 8 of 10 also received CBT. Interviews were transcribed verbatim and analysed using thematic analysis to identify central themes within and among participants' accounts. Results Three super-ordinate thematic areas were...


Exploring Service Users’ Perceptions of Cognitive Behavioural Therapy for Psychosis: A User Led Study

Martina Kilbride, Rory Byrne, Jason Price, Lisa Wood, Sarah Barratt, Mary Welford and Anthony P. Morrison Full Article Abstract Background and aims: This study explored individuals’ subjective experiences of Cognitive Behavioural Therapy for psychosis (CBTp) with the aim of identifying coherent themes consistent across individual accounts and any potential barriers to CBTp effectiveness. Method: Semi-structured interviews were conducted with nine individuals with experience of CBTp. A qualitative Interpretive Phenomenological Analysis was used to analyze the data collected to identify common themes. Results: Five super-ordinate themes emerged from our analyses: CBT as a process of person-centred engagement; CBT as an active process of structured learning; CBT helping to improve personal understanding; CBT is hard work; Recovery and outcomes of CBT for psychosis. Conclusions: The theoretical and clinical implications...


Service Users ’Priorities and Preferences forTreatment of Psychosis: A User-Led Delphi Study

Rory Byrne, B.Sc. Anthony P. Morrison Full Article Objective: Service users may have different priorities and preferences for treatment compared with mental health professionals. Few studies have explored these potentially important differences. This study sought consensus from a sample of service users regarding priorities and preferences for treatment of psychosis. Methods: A three-stage Delphi study exploring treatment priorities and preferences was conducted with a sample of mental health service users (“experts by experience”).Aftergenerationofan initial statement list (stage 1, N56 participants), 64 diverse elements of mental health treatment were rated during a two-stage online survey process (stage 2, N532; stage 3, N521). Results: Fifteen of 64 treatment-related statements were endorsed as important or essential treatment priorities or preferences by more than 80% of participants during stage 2. Two...


Semi-structured Interview Measure of Stigma (SIMS) in psychosis: Assessment of psychometric properties

Lisa Wooda, Eilish Burkeb, Rory Byrne, Gabriela Enachea, Anthony P. Morrison Full Article Abstract Stigma is a significant difficulty for people who experience psychosis. To date, there have been no outcome measures developed to examine stigma exclusively in people with psychosis. The aim of this study was develop and validate a semi-structured interview measure of stigma (SIMS) in psychosis. The SIMS is an eleven item measure of stigma developed in consultation with service users who have experienced psychosis. 79 participants with experience of psychosis were recruited for the purposes of this study. They were administered the SIMS alongside a battery of other relevant outcome measures to examine reliability and validity. A one-factor solution was identified for the SIMS which encompassed all ten rateable items. The measure met...


Design and protocol for the Focusing on Clozapine Unresponsive Symptoms (FOCUS) trial: a randomised controlled trial

Melissa Pyle, John Norrie, Matthias Schwannauer, David Kingdon, Andrew Gumley, Douglas Turkington, Rory Byrne, Suzy Syrett, Graeme MacLennan, Robert Dudley, Hamish J. McLeod, Helen Griffiths, Samantha Bowe, Thomas R. E. Barnes, Paul French, Paul Hutton, Linda Davies and Anthony P. Morrison Full Article Abstract Background For around a third of people with a diagnosis of schizophrenia, the condition proves to respond poorly to treatment with many typical and atypical antipsychotics. This is commonly referred to as treatment-resistant schizophrenia. Clozapine is the only antipsychotic with convincing efficacy for people whose symptoms are considered treatment-resistant to antipsychotic medication. However, 30–40 % of such conditions will have an insufficient response to the drug. Cognitive behavioural therapy has been shown to be an effective treatment for schizophrenia when delivered in combination with antipsychotic medication, with several meta-analyses showing robust support for this approach. However, the evidence for the effectiveness of cognitive behavioural therapy for...