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Publications: 2016 Archives - Psychosis Research Unit
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Publications: 2016

Service Users ’Priorities and Preferences forTreatment of Psychosis: A User-Led Delphi Study

Rory Byrne, B.Sc. Anthony P. Morrison Full Article Objective: Service users may have different priorities and preferences for treatment compared with mental health professionals. Few studies have explored these potentially important differences. This study sought consensus from a sample of service users regarding priorities and preferences for treatment of psychosis. Methods: A three-stage Delphi study exploring treatment priorities and preferences was conducted with a sample of mental health service users (“experts by experience”).Aftergenerationofan initial statement list (stage 1, N56 participants), 64 diverse elements of mental health treatment were rated during a two-stage online survey process (stage 2, N532; stage 3, N521). Results: Fifteen of 64 treatment-related statements were endorsed as important or essential treatment priorities or preferences by more than 80% of participants during stage 2. Two...


Semi-structured Interview Measure of Stigma (SIMS) in psychosis: Assessment of psychometric properties

Lisa Wooda, Eilish Burkeb, Rory Byrne, Gabriela Enachea, Anthony P. Morrison Full Article Abstract Stigma is a significant difficulty for people who experience psychosis. To date, there have been no outcome measures developed to examine stigma exclusively in people with psychosis. The aim of this study was develop and validate a semi-structured interview measure of stigma (SIMS) in psychosis. The SIMS is an eleven item measure of stigma developed in consultation with service users who have experienced psychosis. 79 participants with experience of psychosis were recruited for the purposes of this study. They were administered the SIMS alongside a battery of other relevant outcome measures to examine reliability and validity. A one-factor solution was identified for the SIMS which encompassed all ten rateable items. The measure met...


Design and protocol for the Focusing on Clozapine Unresponsive Symptoms (FOCUS) trial: a randomised controlled trial

Melissa Pyle, John Norrie, Matthias Schwannauer, David Kingdon, Andrew Gumley, Douglas Turkington, Rory Byrne, Suzy Syrett, Graeme MacLennan, Robert Dudley, Hamish J. McLeod, Helen Griffiths, Samantha Bowe, Thomas R. E. Barnes, Paul French, Paul Hutton, Linda Davies and Anthony P. Morrison Full Article Abstract Background For around a third of people with a diagnosis of schizophrenia, the condition proves to respond poorly to treatment with many typical and atypical antipsychotics. This is commonly referred to as treatment-resistant schizophrenia. Clozapine is the only antipsychotic with convincing efficacy for people whose symptoms are considered treatment-resistant to antipsychotic medication. However, 30–40 % of such conditions will have an insufficient response to the drug. Cognitive behavioural therapy has been shown to be an effective treatment for schizophrenia when delivered in combination with antipsychotic medication, with several meta-analyses showing robust support for this approach. However, the evidence for the effectiveness of cognitive behavioural therapy for...


The importance of human relationships, ethics and recovery-orientated values in the delivery of CBT for people with psychosis

Alison Brabban, Rory Byrne, Eleanor Longden & Anthony P. Morrison Full Article Abstract Cognitive behavioural therapy for psychosis (CBTp) is, at times, perceived as a technical therapy that undervalues the importance of human relationships and the fundamental principles on which CBTp itself is based (such as collaboration, validation, optimism and recovery-orientated practice). As such, it can be dismissed by service users or practitioners as undesirable. It is also possible that delivering CBTp that does not adhere to these values can be unhelpful or harmful. We review the evidence regarding what service users want from mental health services and the ability of CBTp to meet these standards. Evidence from qualitative studies and randomised controlled trials suggests that CBTp should be delivered in a manner that is both acceptable...


Don’t just screen intervene; a quality improvement initiative to improve physical health screening of young people experiencing severe mental illness

Greenwood P & Shiers D Full Article Abstract Purpose – The purpose of this paper is to improve the quality of monitoring of risk factors that predict the likelihood of people with severe mental illness (SMI) developing cardiovascular disease (CVD), diabetes and obesity, major contributors to poor physical health and risk of premature mortality. Design/methodology/approach – The first phase of the AQuA “Don’t just screen-intervene” initiative supported five specialised community-based Early Intervention for Psychosis services in North West England to assess the effectiveness of monitoring of cardiometabolic risk in their patients using standards derived from the Lester Positive Cardiometabolic Health Resource, a nationally acknowledged framework for people with psychosis receiving antipsychotic medication. The initial findings formed the basis for a quality improvement programme which ran from November 2012...